SARS-CoV-2 viral load and shedding kinetics

Puelles, V. G. et al. Multiorgan and renal tropism of SARS-CoV-2. N. Engl. J. Med. 383, 590–592 (2020).

Article 
PubMed 

Google Scholar 

Lamers, M. M. & Haagmans, B. L. SARS-CoV-2 pathogenesis. Nat. Rev. Microbiol. 20, 270–284 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Peng, L. et al. SARS-CoV-2 can be detected in urine, blood, anal swabs, and oropharyngeal swabs specimens. J. Med. Virol. 92, 1676–1680 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Nature 581, 465–469 (2020).

Article 
PubMed 

Google Scholar 

Zhang, W. et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerg. Microbes Infect. 9, 386–389 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Pérez-Bartolomé, F. & Sánchez-Quirós, J. Ocular manifestations of SARS-CoV-2: literature review. Arch. Soc. Esp. Oftalmol. 96, 32–40 (2021).

Article 
PubMed 

Google Scholar 

Vetter, P. et al. Daily viral kinetics and innate and adaptive immune response assessment in COVID-19: a case series. mSphere https://doi.org/10.1128/mSphere.00827-20 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar 

Jeong, H. W. et al. Viable SARS-CoV-2 in various specimens from COVID-19 patients. Clin. Microbiol. Infect. 26, 1520–1524 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Cerrada-Romero, C. et al. Excretion and viability of SARS-CoV-2 in feces and its association with the clinical outcome of COVID-19. Sci. Rep. 12, 7397 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Dergham, J. & Delerce, J. Isolation of viable SARS-CoV-2 virus from feces of an immunocompromised patient suggesting a possible fecal mode of transmission. J. Clin. Med. https://doi.org/10.3390/jcm10122696 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Xiao, F. et al. Infectious SARS-CoV-2 in feces of patient with severe COVID-19. Emerg. Infect. Dis. 26, 1920–1922 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Sun, J. et al. Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient. Emerg. Microbes Infect. 9, 991–993 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Colavita, F. et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann. Intern. Med. 173, 242–243 (2020).

Article 
PubMed 

Google Scholar 

Matsuyama, S. et al. Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells. Proc. Natl Acad. Sci. USA 117, 7001–7003 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Case, J. B., Bailey, A. L., Kim, A. S., Chen, R. E. & Diamond, M. S. Growth, detection, quantification, and inactivation of SARS-CoV-2. Virology 548, 39–48 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Baggen, J., Vanstreels, E., Jansen, S. & Daelemans, D. Cellular host factors for SARS-CoV-2 infection. Nat. Microbiol. 6, 1219–1232 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Chu, H. et al. Comparative tropism, replication kinetics, and cell damage profiling of SARS-CoV-2 and SARS-CoV with implications for clinical manifestations, transmissibility, and laboratory studies of COVID-19: an observational study. Lancet Microbe 1, e14–e23 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

van Kampen, J. J. A. et al. Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19). Nat. Commun. 12, 267 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Bruce, E. A. et al. Predicting infectivity: comparing four PCR-based assays to detect culturable SARS-CoV-2 in clinical samples. EMBO Mol. Med. 14, e15290 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Essaidi-Laziosi, M. & Perez Rodriguez, F. J. Estimating clinical SARS-CoV-2 infectiousness in Vero E6 and primary airway epithelial cells. Lancet Microbe 2, e571 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Liu, R. et al. Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020. Clin. Chim. Acta 505, 172–175 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Corman, V. M. et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eur. Surveill. https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045 (2020).

Article 

Google Scholar 

Bullard, J. et al. Predicting infectious severe acute respiratory syndrome coronavirus 2 from diagnostic samples. Clin. Infect. Dis. 71, 2663–2666 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Jefferson, T., Spencer, E. A., Brassey, J. & Heneghan, C. Viral cultures for coronavirus disease 2019 infectivity assessment: a systematic review. Clin. Infect. Dis. 73, e3884–e3899 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Puhach, O. et al. Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2. Nat. Med. 28, 1491–1500 (2022).

Article 
CAS 
PubMed 

Google Scholar 

van Kasteren, P. B. et al. Comparison of seven commercial RT-PCR diagnostic kits for COVID-19. J. Clin. Virol. 128, 104412 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar 

Bentley, E. et al. Collaborative study for the establishment of a WHO international standard for SARS-CoV-2 RNA (WHO, 2020).

Zou, L. et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N. Engl. J. Med. 382, 1177–1179 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar 

Killingley, B. et al. Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults. Nat. Med. 28, 1031–1041 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Yu, F. et al. Quantitative detection and viral load analysis of SARS-CoV-2 in infected patients. Clin. Infect. Dis. 71, 793–798 (2020).

Article 
CAS 
PubMed 

Google Scholar 

European Centre for Disease Prevention and Control & World Health Organization Regional Office for Europe. Methods for the detection and identification of SARS-CoV-2 variants: second update, August 2022 (WHO, 2022).

Ke, R. et al. Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveals limited infectious virus shedding and restricted tissue distribution. Open Forum Infect. Dis. 9, ofac192 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Ke, R. et al. Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness. Nat. Microbiol. 7, 640–652 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Pekosz, A. et al. Antigen-based testing but not real-time polymerase chain reaction correlates with severe acute respiratory syndrome coronavirus 2 viral culture. Clin. Infect. Dis. 73, e2861–e2866 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Monel, B. et al. Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-Alpha or Alpha SARS-CoV-2 variants: an observational retrospective study. EBioMedicine 73, 103637 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kirby, J. E. et al. SARS-CoV-2 antigen tests predict infectivity based on viral culture: comparison of antigen, PCR viral load, and viral culture testing on a large sample cohort. Clin. Microbiol. Infect. https://doi.org/10.1016/j.cmi.2022.07.010 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Pickering, S. et al. Comparative performance of SARS-CoV-2 lateral flow antigen tests and association with detection of infectious virus in clinical specimens: a single-centre laboratory evaluation study. Lancet Microbe 2, e461–e471 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Tariq, M. et al. Viable severe acute respiratory syndrome coronavirus 2 isolates exhibit higher correlation with rapid antigen assays than subgenomic RNA or genomic RNA. Front. Microbiol. 12, 718497 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Chu, V. T. et al. Comparison of home antigen testing with RT-PCR and viral culture during the course of SARS-CoV-2 infection. JAMA Intern. Med. 182, 701–709 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Albert, E. et al. Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag rapid test device) for COVID-19 diagnosis in primary healthcare centres. Clin. Microbiol. Infect. 27, 472.e7–472.e10 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Ford, L. et al. Epidemiologic characteristics associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-based test results, real-time reverse transcription polymerase chain reaction (rRT-PCR) cycle threshold values, subgenomic RNA, and viral culture results from university testing. Clin. Infect. Dis. 73, e1348–e1355 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Berger, A. et al. Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers. PLoS ONE 16, e0248921 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Brümmer, L. E. et al. Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: a living systematic review and meta-analysis. PLoS Med. 18, e1003735 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Ngo Nsoga, M. T. et al. Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2. PLoS ONE 16, e0253321 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Korenkov, M. et al. Evaluation of a rapid antigen test to detect SARS-CoV-2 infection and identify potentially infectious individuals. J. Clin. Microbiol. 59, e0089621 (2021).

Article 
PubMed 

Google Scholar 

Yamayoshi, S. et al. Comparison of rapid antigen tests for COVID-19. Viruses 12, 1420 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

McKay, S. L. et al. Performance evaluation of serial SARS-CoV-2 rapid antigen testing during a nursing home outbreak. Ann. Intern. Med. 174, 945–951 (2021).

Article 
PubMed 

Google Scholar 

Nordgren, J. et al. SARS-CoV-2 rapid antigen test: high sensitivity to detect infectious virus. J. Clin. Virol. 140, 104846 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Fernandez-Montero, A. & Argemi, J. Validation of a rapid antigen test as a screening tool for SARS-CoV-2 infection in asymptomatic populations. Sensitivity, specificity and predictive values. EClinicalMedicine 37, 100954 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Currie, D. W. et al. Relationship of SARS-CoV-2 antigen and reverse transcription PCR positivity for viral cultures. Emerg. Infect. Dis. 28, 717–720 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Corman, V. M. et al. Comparison of seven commercial SARS-CoV-2 rapid point-of-care antigen tests: a single-centre laboratory evaluation study. Lancet Microbe 2, e311–e319 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lopera, T. J. & Alzate-Ángel, J. C. The usefulness of antigen testing in predicting contagiousness in COVID-19. Microbiol. Spectr. 10, e0196221 (2022).

Article 
PubMed 

Google Scholar 

Osterman, A. et al. Impaired detection of Omicron by SARS-CoV-2 rapid antigen tests. Med. Microbiol. Immunol. 211, 105–117 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Galliez, R. M. et al. Evaluation of the Panbio COVID-19 antigen rapid diagnostic test in subjects infected with Omicron using different specimens. Microbiol. Spectr. 10, e0125022 (2022).

Article 
PubMed 

Google Scholar 

Raïch-Regué, D. et al. Performance of SARS-CoV-2 antigen-detecting rapid diagnostic tests for Omicron and other variants of concern. Front. Microbiol. 13, 810576 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

van Ogtrop, M. L., van de Laar, T. J. W., Eggink, D., Vanhommerig, J. W. & van der Reijden, W. A. Comparison of the performance of the Panbio COVID-19 antigen test in SARS-CoV-2 B.1.1.7 (Alpha) variants versus non-B.1.1.7 variants. Microbiol. Spectr. 9, e0088421 (2021).

Article 
PubMed 

Google Scholar 

Lindner, A. K. et al. Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with self-collected nasal swab versus professional-collected nasopharyngeal swab. Eur. Respir. J. 57, 2003961 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Meiners, L. & Horn, J. SARS-CoV-2 rapid antigen test sensitivity and viral load in freshly symptomatic hospital employees, December 2020 to February 2022. Preprint at https://doi.org/10.2139/ssrn.4099425 (2022).

He, X. et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat. Med. 26, 672–675 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Néant, N. et al. Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort. Proc. Natl Acad. Sci. USA 118, e2017962118 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Owusu, D. et al. Persistent SARS-CoV-2 RNA shedding without evidence of infectiousness: a cohort study of individuals with COVID-19. J. Infect. Dis. 224, 1362–1371 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Cevik, M. et al. SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis. Lancet Microbe 2, e13–e22 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Chen, X. et al. Associations of clinical characteristics and treatment regimens with the duration of viral RNA shedding in patients with COVID-19. Int. J. Infect. Dis. 98, 252–260 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kim, S. M. & Hwang, Y. J. Prolonged SARS-CoV-2 detection and reversed RT-PCR results in mild or asymptomatic patients. Infect. Dis. 53, 31–37 (2021).

Article 
CAS 

Google Scholar 

Talmy, T. & Tsur, A. Duration of SARS-CoV-2 detection in Israel Defense Forces soldiers with mild COVID-19. J. Med. Virol. 93, 608–610 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Singanayagam, A. et al. Duration of infectiousness and correlation with RT-PCR cycle threshold values in cases of COVID-19, England, January to May 2020. Euro Surveill. https://doi.org/10.2807/1560-7917.ES.2020.25.32.2001483 (2020).

Perera, R. et al. SARS-CoV-2 virus culture and subgenomic RNA for respiratory specimens from patients with mild coronavirus disease. Emerg. Infect. Dis. 26, 2701–2704 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Killerby, M. E. et al. Shedding of culturable virus, seroconversion, and 6-month follow-up antibody responses in the first 14 confirmed cases of coronavirus disease 2019 in the United States. J. Infect. Dis. 224, 771–776 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Glans, H. et al. Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to serum antibody responses. BMC Infect. Dis. 21, 494 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Badu, K. et al. SARS-CoV-2 viral shedding and transmission dynamics: implications of WHO COVID-19 discharge guidelines. Front. Med. 8, 648660 (2021).

Article 

Google Scholar 

Munker, D. et al. Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients. Eur. Respir. J. 58, 2002724 (2021).

Article 
PubMed 

Google Scholar 

Folgueira, M. D. & Luczkowiak, J. Prolonged SARS-CoV-2 cell culture replication in respiratory samples from patients with severe COVID-19. Clin. Microbiol. Infect. 27, 886–891 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kim, M. C. et al. Duration of culturable SARS-CoV-2 in hospitalized patients with Covid-19. N. Engl. J. Med. 384, 671–673 (2021).

Article 
PubMed 

Google Scholar 

Chen, P. Z. et al. SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19. eLife https://doi.org/10.7554/eLife (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Cunha, M. D. P. et al. Atypical prolonged viral shedding with intra-host SARS-CoV-2 evolution in a mildly affected symptomatic patient. Front. Med. 8, 760170 (2021).

Article 

Google Scholar 

Aydillo, T. et al. Shedding of viable SARS-CoV-2 after immunosuppressive therapy for cancer. N. Engl. J. Med. 383, 2586–2588 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Caillard, S., Benotmane, I., Gautier Vargas, G., Perrin, P. & Fafi-Kremer, S. SARS-CoV-2 viral dynamics in immunocompromised patients. Am. J. Transpl. 21, 1667–1669 (2021).

Article 
CAS 

Google Scholar 

Roedl, K. et al. Viral dynamics of SARS-CoV-2 in critically ill allogeneic hematopoietic stem cell transplant recipients and immunocompetent patients with COVID-19. Am. J. Respir. Crit. Care Med. 203, 242–245 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Leung, W. F. et al. COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report. Int. J. Infect. Dis. 114, 178–182 (2022).

Article 
CAS 
PubMed 

Google Scholar 

European Centre for Disease Prevention and Control. Rapid risk assessment: assessing SARS-CoV-2 circulation, variants of concern, non-pharmaceutical interventions and vaccine rollout in the EU/EEA, 15th update (European Centre for Disease Prevention and Control, 2021).

Grant, R. et al. Impact of SARS-CoV-2 Delta variant on incubation, transmission settings and vaccine effectiveness: results from a nationwide case–control study in France. Lancet Reg. Health Eur. 13, 100278 (2022).

Article 
PubMed 

Google Scholar 

Ogata, T. & Tanaka, H. Shorter incubation period among unvaccinated Delta variant coronavirus disease 2019 patients in Japan. Int. J. Environ. Res. Public Health https://doi.org/10.3390/ijerph19031127 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Backer, J. A. et al. Shorter serial intervals in SARS-CoV-2 cases with Omicron BA.1 variant compared with Delta variant, the Netherlands, 13 to 26 December 2021. Eur. Surveill. https://doi.org/10.2807/1560-7917.ES.2022.27.6.2200042 (2022).

Article 

Google Scholar 

Takahashi, K. et al. Duration of infectious virus shedding by SARS-CoV-2 Omicron variant-infected vaccinees. Emerg. Infect. Dis. 28, 998–1001 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Boucau, J. et al. Duration of shedding of culturable virus in SARS-CoV-2 Omicron (BA.1) infection. N. Engl. J. Med. 387, 275–277 (2022).

Article 
PubMed 

Google Scholar 

Jones, T. C. et al. Estimating infectiousness throughout SARS-CoV-2 infection course. Science https://doi.org/10.1126/science.abi5273 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Li, B. et al. Viral infection and transmission in a large, well-traced outbreak caused by the SARS-CoV-2 Delta variant. Nat. Commun. 13, 460 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Bolze, A. et al. SARS-CoV-2 variant Delta rapidly displaced variant Alpha in the United States and led to higher viral loads. Cell Rep. Med. 3, 100564 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Earnest, R. et al. Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA. Cell Rep. Med. 3, 100583 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Luo, C. H. et al. Infection with the SARS-CoV-2 Delta variant is associated with higher recovery of infectious virus compared to the Alpha variant in both unvaccinated and vaccinated individuals. Clin. Infect. Dis. 75, e715–e725 (2021).

Article 

Google Scholar 

Despres, H. W. et al. Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer: RNA ratio for Delta and Epsilon vs. Alpha variants. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.2116518119 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Hay, J. A. et al. Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: a retrospective cohort study. eLife 11, e81849 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Fall, A. et al. The displacement of the SARS-CoV-2 variant Delta with Omicron: an investigation of hospital admissions and upper respiratory viral loads. EbioMedicine https://doi.org/10.1016/j.ebiom.2022.104008 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Lentini, A. & Pereira, A. Monitoring of the SARS-CoV-2 Omicron BA.1/BA.2 lineage transition in the Swedish population reveals increased viral RNA levels in BA.2 cases. Med 3, 636–664 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Qassim, S. H. et al. Effects of BA.1/BA.2 subvariant, vaccination, and prior infection on infectiousness of SARS-CoV-2 Omicron infections. J. Travel Med. 29, taac068 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Marking, U. et al. Correlates of protection, viral load trajectories and symptoms in BA.1, BA.1.1 and BA.2 breakthrough infections in triple vaccinated healthcare workers. Preprint at medRxiv https://doi.org/10.1101/2022.04.02.22273333 (2022).

Article 

Google Scholar 

Wang, Y. et al. Transmission, viral kinetics and clinical characteristics of the emergent SARS-CoV-2 Delta VOC in Guangzhou, China. EClinicalMedicine 40, 101129 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Siedner, M. J. et al. Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 Delta variant infections. JCI Insight https://doi.org/10.1172/jci.insight.155483 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Pierce, C. A. et al. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Sci. Transl Med. 12, eabd5487 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Takahashi, T. et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature 588, 315–320 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Bunyavanich, S., Do, A. & Vicencio, A. Nasal gene expression of angiotensin-converting enzyme 2 in children and adults. JAMA 323, 2427–2429 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Zheng, S. et al. Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January–March 2020: retrospective cohort study. BMJ 369, m1443 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar 

L’Huillier, A. G. & Torriani, G. Culture-competent SARS-CoV-2 in nasopharynx of symptomatic neonates, children, and adolescents. Emerg. Infect. Dis. 26, 2494–2497 (2020).

Article 
PubMed 
PubMed Central 

Google Scholar 

Baggio, S. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load in the upper respiratory tract of children and adults with early acute coronavirus disease 2019 (COVID-19). Clin. Infect. Dis. 73, 148–150 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Chung, E. et al. Comparison of symptoms and RNA levels in children and adults with SARS-CoV-2 infection in the community setting. JAMA Pediatr. 175, e212025 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Han, M. S. et al. Clinical characteristics and viral RNA detection in children with coronavirus disease 2019 in the Republic of Korea. JAMA Pediatr. 175, 73–80 (2021).

Article 
PubMed 

Google Scholar 

Bellon, M. et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load kinetics in symptomatic children, adolescents, and adults. Clin. Infect. Dis. 73, e1384–e1386 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Madera, S. et al. Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults. Sci. Rep. 11, 3044 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lauer, S. A. et al. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Ann. Intern. Med. 172, 577–582 (2020).

Article 
PubMed 

Google Scholar 

Elias, C., Sekri, A., Leblanc, P., Cucherat, M. & Vanhems, P. The incubation period of COVID-19: a meta-analysis. Int. J. Infect. Dis. 104, 708–710 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Dhouib, W. et al. The incubation period during the pandemic of COVID-19: a systematic review and meta-analysis. Syst. Rev. 10, 101 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Brandal, L. T. et al. Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021. Eur. Surveill. 26, 2101147 (2021).

Article 
CAS 

Google Scholar 

Wu, Y. et al. Incubation period of COVID-19 caused by unique SARS-CoV-2 strains: a systematic review and meta-analysis. JAMA Netw. Open 5, e2228008 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Sun, K. et al. Transmission heterogeneities, kinetics, and controllability of SARS-CoV-2. Science 371, eabe2424 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Lavezzo, E. et al. Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’. Nature 584, 425–429 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Gudbjartsson, D. F. et al. Spread of SARS-CoV-2 in the Icelandic population. N. Engl. J. Med. 382, 2302–2315 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Glenet, M. et al. Asymptomatic COVID-19 adult outpatients identified as significant viable SARS-CoV-2 shedders. Sci. Rep. 11, 20615 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Wang, Y. et al. Characterization of an asymptomatic cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals outside of Wuhan, China. Clin. Infect. Dis. 71, 2132–2138 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Long, Q. X. et al. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections. Nat. Med. 26, 1200–1204 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Lee, S. et al. Clinical course and molecular viral shedding among asymptomatic and symptomatic patients with SARS-CoV-2 infection in a community treatment center in the Republic of Korea. JAMA Intern. Med. 180, 1447–1452 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Zhou, R. et al. Viral dynamics in asymptomatic patients with COVID-19. Int. J. Infect. Dis. 96, 288–290 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Hall, S. M. et al. Comparison of anterior nares CT values in asymptomatic and symptomatic individuals diagnosed with SARS-CoV-2 in a university screening program. PLoS ONE 17, e0270694 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kissler, S. M. et al. Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies. PLoS Biol. 19, e3001333 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Tallmadge, R. L. et al. Viral RNA load and infectivity of SARS-CoV-2 in paired respiratory and oral specimens from symptomatic, asymptomatic, or postsymptomatic individuals. Microbiol. Spectr. 10, e0226421 (2022).

Article 
PubMed 

Google Scholar 

Marks, M. et al. Transmission of COVID-19 in 282 clusters in Catalonia, Spain: a cohort study. Lancet Infect. Dis. 21, 629–636 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Marc, A. et al. Quantifying the relationship between SARS-CoV-2 viral load and infectiousness. eLife https://doi.org/10.7554/eLife.69302 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Cheng, H. Y. et al. Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset. JAMA Intern. Med. 180, 1156–1163 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Mugglestone, M. A. et al. Presymptomatic, asymptomatic and post-symptomatic transmission of SARS-CoV-2: joint British Infection Association (BIA), Healthcare Infection Society (HIS), Infection Prevention Society (IPS) and Royal College of Pathologists (RCPath) guidance. BMC Infect. Dis. 22, 453 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Eyre, D. W. et al. Effect of Covid-19 vaccination on transmission of Alpha and Delta variants. N. Engl. J. Med. 386, 744–756 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Prunas, O. et al. Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel. Science 375, 1151–1154 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lyngse, F. P. et al. Household transmission of SARS-CoV-2 Omicron variant of concern subvariants BA.1 and BA.2 in Denmark. Nat. Commun. 13, 5760 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Leung, N. H. L. Transmissibility and transmission of respiratory viruses. Nat. Rev. Microbiol. 19, 528–545 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Alihsan, B. et al. The efficacy of facemasks in the prevention of COVID-19: a systematic review. Preprint at medRxiv https://doi.org/10.1101/2022.07.28.22278153 (2022).

Article 

Google Scholar 

Hu, Z. et al. Early immune markers of clinical, virological, and immunological outcomes in patients with COVID-19: a multi-omics study. Elife 11, e77943 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Chen, P. Z. et al. Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols. eLife https://doi.org/10.7554/eLife.65774 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Adam, D. C. et al. Clustering and superspreading potential of SARS-CoV-2 infections in Hong Kong. Nat. Med. 26, 1714–1719 (2020).

Article 
CAS 
PubMed 

Google Scholar 

Guo, Z. et al. Superspreading potential of infection seeded by the SARS-CoV-2 Omicron BA.1 variant in South Korea. J. Infect. 85, e77–e79 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Guo, Z. et al. Superspreading potential of COVID-19 outbreak seeded by Omicron variants of SARS-CoV-2 in Hong Kong. J. Travel Med. 29, taac049 (2022).

Article 
PubMed 

Google Scholar 

Althouse, B. M. et al. Superspreading events in the transmission dynamics of SARS-CoV-2: opportunities for interventions and control. PLoS Biol. 18, e3000897 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Baden, L. R. et al. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N. Engl. J. Med. 384, 403–416 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Lopez Bernal, J. et al. Effectiveness of Covid-19 vaccines against the B.1.617.2 (Delta) variant. N. Engl. J. Med. 385, 585–594 (2021).

Article 
PubMed 

Google Scholar 

Feikin, D. R. et al. Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression. Lancet 399, 924–944 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Belik, M. et al. Comparative analysis of COVID-19 vaccine responses and third booster dose-induced neutralizing antibodies against Delta and Omicron variants. Nat. Commun. 13, 2476 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Pegu, A. et al. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science 373, 1372–1377 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lipsitch, M., Krammer, F., Regev-Yochay, G., Lustig, Y. & Balicer, R. D. SARS-CoV-2 breakthrough infections in vaccinated individuals: measurement, causes and impact. Nat. Rev. Immunol. 22, 57–65 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Mostaghimi, D., Valdez, C. N., Larson, H. T., Kalinich, C. C. & Iwasaki, A. Prevention of host-to-host transmission by SARS-CoV-2 vaccines. Lancet Infect. Dis. https://doi.org/10.1016/S1473-3099(21)00472-2 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Russell, M. W., Moldoveanu, Z., Ogra, P. L. & Mestecky, J. Mucosal immunity in COVID-19: a neglected but critical aspect of SARS-CoV-2 infection. Front. Immunol. 11, 611337 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Sheikh-Mohamed, S. et al. Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection. Mucosal Immunol. 15, 799–808 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Collier, A. Y. et al. Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 Delta variant. Sci. Transl Med. 14, eabn6150 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Pouwels, K. B. et al. Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK. Nat. Med. 27, 2127–2135 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Singanayagam, A. et al. Community transmission and viral load kinetics of the SARS-CoV-2 Delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study. Lancet Infect. Dis. 22, 183–195 (2021).

Article 
PubMed 

Google Scholar 

Levine-Tiefenbrun, M. et al. Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2. Nat. Med. 27, 2108–2110 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Emary, K. R. W. et al. Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial. Lancet 397, 1351–1362 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Chia, P. Y. et al. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine breakthrough infections: a multicentre cohort study. Clin. Microbiol. Infect. 28, 612.e1–612.e7 (2021).

Article 
PubMed 

Google Scholar 

Garcia-Knight, M. et al. Infectious viral shedding of SARS-CoV-2 Delta following vaccination: a longitudinal cohort study. PLoS Pathog. 18, e1010802 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Peña-Hernández, M. A. et al. Comparison of infectious SARS-CoV-2 from the nasopharynx of vaccinated and unvaccinated individuals. Preprint at medRxiv https://doi.org/10.1101/2021.12.28.21268460 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Shamier, M. C. et al. Virological characteristics of SARS-CoV-2 vaccine breakthrough infections in health care workers. Preprint at medRxiv https://doi.org/10.1101/2021.08.20.21262158 (2021).

Article 

Google Scholar 

Jung, J. et al. Transmission and infectious SARS-CoV-2 shedding kinetics in vaccinated and unvaccinated individuals. JAMA Netw. Open 5, e2213606 (2022).

Article 
PubMed 
PubMed Central 

Google Scholar 

Hirotsu, Y. et al. Similar viral loads in Omicron infections regardless of vaccination status. Preprint at medRxiv https://doi.org/10.1101/2022.04.19.22274005 (2022).

Article 

Google Scholar 

Letizia, A. G. et al. SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study. Lancet Respir. Med. 9, 712–720 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Pulliam, J. R. C. et al. Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa. Science 376, eabn4947 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Harris, R. J. et al. Effect of vaccination on household transmission of SARS-CoV-2 in England. N. Engl. J. Med. 385, 759–760 (2021).

Article 
PubMed 

Google Scholar 

Bates, T. A. et al. Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants. Sci. Immunol. 7, eabn8014 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Wratil, P. R. et al. Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern. Nat. Med. 28, 496–503 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Malato, J. et al. Risk of BA.5 infection among persons exposed to previous SARS-CoV-2 variants. N. Engl. J. Med. 387, 953–954 (2022).

Article 
PubMed 

Google Scholar 

Cao, Y. et al. BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608, 593–602 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Hassan, A. O. et al. A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2. Cell 183, 169–184 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Lapuente, D. et al. Protective mucosal immunity against SARS-CoV-2 after heterologous systemic prime-mucosal boost immunization. Nat. Commun. 12, 6871 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Afkhami, S. et al. Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell 185, 896–915 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Grubaugh, N. D. & Hodcroft, E. B. Public health actions to control new SARS-CoV-2 variants. Cell 184, 1127–1132 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Carreño, J. M. et al. Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature 602, 682–688 (2022).

Article 
PubMed 

Google Scholar 

Ashcroft, P., Lehtinen, S. & Bonhoeffer, S. Test-trace-isolate-quarantine (TTIQ) intervention strategies after symptomatic COVID-19 case identification. PLoS ONE 17, e0263597 (2022).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Santos Bravo, M. et al. Viral culture confirmed SARS-CoV-2 subgenomic RNA value as a good surrogate marker of infectivity. J. Clin. Microbiol. 60, e0160921 (2022).

Article 
PubMed 

Google Scholar 

Kim, J. Y. et al. Diagnostic usefulness of subgenomic RNA detection of viable SARS-CoV-2 in patients with COVID-19. Clin. Microbiol. Infect. 28, 101–106 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Alexandersen, S. & Chamings, A. SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication. Nat. Commun. 11, 6059 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Bonenfant, G. et al. Surveillance and correlation of SARS-CoV-2 viral RNA, antigen, virus isolation, and self-reported symptoms in a longitudinal study with daily sampling. Clin. Infect. Dis. https://doi.org/10.1093/cid/ciac282 (2022).

Article 
PubMed 

Google Scholar 

Peeling, R. W., Heymann, D. L., Teo, Y. Y. & Garcia, P. J. Diagnostics for COVID-19: moving from pandemic response to control. Lancet 399, 757–768 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Pilarowski, G. et al. Performance characteristics of a rapid severe acute respiratory syndrome coronavirus 2 antigen detection assay at a public plaza testing site in San Francisco. J. Infect. Dis. 223, 1139–1144 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Leber, W. et al. Comparing the diagnostic accuracy of point-of-care lateral flow antigen testing for SARS-CoV-2 with RT-PCR in primary care (REAP-2). EClinicalMedicine 38, 101011 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Kohmer, N. et al. The comparative clinical performance of four SARS-CoV-2 rapid antigen tests and their correlation to infectivity in vitro. J. Clin. Med. https://doi.org/10.3390/jcm10020328 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Wang, W. et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA 323, 1843–1844 (2020).

CAS 
PubMed 
PubMed Central 

Google Scholar 

Lee, R. A., Herigon, J. C., Benedetti, A., Pollock, N. R. & Denkinger, C. M. Performance of saliva, oropharyngeal swabs, and nasal swabs for SARS-CoV-2 molecular detection: a systematic review and meta-analysis. J. Clin. Microbiol. 59, e02881-20 (2021).

Tsang, N. N. Y. et al. Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis. Lancet Infect. Dis. 21, 1233–1245 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Peto, T. COVID-19: rapid antigen detection for SARS-CoV-2 by lateral flow assay: a national systematic evaluation of sensitivity and specificity for mass-testing. EClinicalMedicine 36, 100924 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Hay, J. A. et al. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science 373, eabh0635 (2021).

Article 
PubMed 

Google Scholar 

Peccia, J. et al. Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics. Nat. Biotechnol. 38, 1164–1167 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Xin, H. et al. The incubation period distribution of coronavirus disease 2019: a systematic review and meta-analysis. Clin. Infect. Dis. 73, 2344–2352 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Yu, I. T. et al. Evidence of airborne transmission of the severe acute respiratory syndrome virus. N. Engl. J. Med. 350, 1731–1739 (2004).

Article 
CAS 
PubMed 

Google Scholar 

Cheng, P. K. et al. Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome. Lancet 363, 1699–1700 (2004).

Article 
PubMed 
PubMed Central 

Google Scholar 

Peiris, J. S. et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361, 1767–1772 (2003).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Chan, P. K. S. et al. Laboratory diagnosis of SARS. Emerg. Infect. Dis. 10, 825–831 (2004).

Article 
PubMed 
PubMed Central 

Google Scholar 

Liu, W. et al. Long-term SARS coronavirus excretion from patient cohort, China. Emerg. Infect. Dis. 10, 1841–1843 (2004).

Article 
PubMed 
PubMed Central 

Google Scholar 

Xu, D. et al. Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. Eur. J. Clin. Microbiol. Infect. Dis. 24, 165–171 (2005).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

V’Kovski, P. et al. Disparate temperature-dependent virus–host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium. PLoS Biol. 19, e3001158 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

Pitzer, V. E., Leung, G. M. & Lipsitch, M. Estimating variability in the transmission of severe acute respiratory syndrome to household contacts in Hong Kong, China. Am. J. Epidemiol. 166, 355–363 (2007).

Article 
PubMed 

Google Scholar 

Riley, S. et al. Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions. Science 300, 1961–1966 (2003).

Article 
CAS 
PubMed 

Google Scholar 

Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. & Fouchier, R. A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N. Engl. J. Med. 367, 1814–1820 (2012).

Article 
CAS 
PubMed 

Google Scholar 

Breban, R., Riou, J. & Fontanet, A. Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk. Lancet 382, 694–699 (2013).

Article 
PubMed 
PubMed Central 

Google Scholar 

Oh, M. D. et al. Viral load kinetics of MERS coronavirus infection. N. Engl. J. Med. 375, 1303–1305 (2016).

Article 
PubMed 

Google Scholar 

Corman, V. M. et al. Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus Infection. Clin. Infect. Dis. 62, 477–483 (2016).

CAS 
PubMed 

Google Scholar 

Min, C.-K. et al. Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity. Sci. Rep. 6, 25359 (2016).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Ip, D. K. et al. Viral shedding and transmission potential of asymptomatic and paucisymptomatic influenza virus infections in the community. Clin. Infect. Dis. 64, 736–742 (2017).

PubMed 

Google Scholar 

Carrat, F. et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am. J. Epidemiol. 167, 775–785 (2008).

Article 
PubMed 

Google Scholar 

Pawelek, K. A. et al. Modeling within-host dynamics of influenza virus infection including immune responses. PLoS Comput. Biol. 8, e1002588 (2012).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Ip, D. K. M. et al. The dynamic relationship between clinical symptomatology and viral shedding in naturally acquired seasonal and pandemic influenza virus infections. Clin. Infect. Dis. 62, 431–437 (2016).

PubMed 

Google Scholar 

Nair, H. et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 375, 1545–1555 (2010).

Article 
PubMed 
PubMed Central 

Google Scholar 

Bagga, B. et al. Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals. Antivir. Ther. 18, 785–791 (2013).

Article 
CAS 
PubMed 

Google Scholar 

DeVincenzo, J. P. et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am. J. Respir. Crit. Care Med. 182, 1305–1314 (2010).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kutter, J. S. et al. Small quantities of respiratory syncytial virus RNA only in large droplets around infants hospitalized with acute respiratory infections. Antimicrob. Resist. Infect. Control 10, 100 (2021).

Article 
PubMed 
PubMed Central 

Google Scholar 

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