A new study from the University of Missouri School of Medicine is the first human evidence that short-term lifestyle changes can alter the insulin response of blood vessels. It is also the first study to show that men and women react differently to these changes.
Vascular insulin resistance is a feature of obesity and type 2 diabetes that contributes to vascular disease. The researchers examined vascular insulin resistance in 36 healthy young men and women by exposing them to 10 days of reduced physical activity, reducing their step count from 10,000 to 5,000 steps per day. The participants also increased their consumption of sugary drinks to six cans of soda a day.
We know that the incidence of insulin resistance and cardiovascular disease is lower in premenopausal women than in men, but we wanted to see how men and women reacted to reduced physical activity and increased sugar in their diets over a period of time. short period of time”.
Camila Manrique-Acevedo, MD, Associate Professor of Medicine
The results showed that only in men did the sedentary lifestyle and high sugar intake cause a decrease in insulin-stimulated blood flow in the legs and a drop in a protein called adropin, which regulates insulin sensitivity and is an important biomarker for cardiovascular disease.
“These findings underline a sex-related difference in the development of vascular insulin resistance induced by the adoption of a high-sugar, low-exercise lifestyle,” Manrique-Acevedo said. “To our knowledge, this is the first evidence in humans that vascular insulin resistance can be triggered by adverse short-term changes in lifestyle, and it is the first documentation of sex-related differences in the development of Vascular insulin resistance in association with changes in adropin levels”.
Manrique-Acevedo said she would next like to examine how long it takes to reverse these vascular and metabolic changes and more fully assess the impact of the role of gender in the development of vascular insulin resistance.
The entire MU research team included Jaume Padilla, PhD, associate professor of nutrition and exercise physiology and co-author of this paper; Luis Martinez-Lemus, DVM, PhD, professor of pharmacology and medical physiology, and R. Scott Rector, PhD, associate professor of nutrition. It also included postdoctoral fellows Rogerio Soares, PhD; and graduate students James A. Smith and Thomas Jurrissen.
Their study, “Young women are protected against vascular insulin resistance induced by adopting an obesogenic lifestyle,” was recently published in the journal Endocrinology. Some support for this study was provided by the National Institutes of Health and a VA Merit Grant. The content does not necessarily represent the official views of the funding agency. The authors declare that they have no potential conflict of interest.
Manrique-Acevedo and his collaborators work out of the Roy Blunt NextGen Precision Health building at MU, which anchors the statewide initiative to unite government and industry leaders with innovators from the system’s four research universities in pursuit of health advances. of precision that change the life. The University of Missouri System’s bold NextGen initiative highlights the promise of personalized healthcare and the impact of large-scale interdisciplinary collaboration.
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University of Missouri-Columbia
Magazine reference:
Smith, JA, et al. (2022). Young women are protected against vascular insulin resistance induced by adopting an obesogenic lifestyle. Endocrinology. doi.org/10.1210/endocr/bqac137.
Source: news.google.com