WEDNESDAY, Dec. 7, 2022 (HealthDay News) — A significant proportion of the burden of ulcerative colitis (UC) and Crohn’s disease (CD) could be prevented by lifestyle changes, according to a study published online Dec. 6 December in Gut.
Emily W. Lopes, MD, MPH, of Massachusetts General Hospital in Boston, and colleagues conducted a prospective cohort study of 72,290 US adults from the Nurses’ Health Study (NHS), 93,909 from the NHSII, and 41,871 from the Follow-up of Health Professionals. upstairs Study. Based on established lifestyle risk factors, modifiable risk scores (MRS; 0 to 6) were created for CD and UC; Healthy lifestyle scores (0 to 9) were derived from the American healthy lifestyle recommendations. The population attributable risk was calculated by comparing the incidence of CD and UC between the low and high risk groups. The findings were externally validated in three European cohorts.
The investigators found that 346 CD and 456 UC cases were documented during 5,117,021 person-years of follow-up. Overall, 42.9 and 44.4 percent of CD and UC cases could have been prevented with low MRS adherence. Similarly, 61.1 and 42.2 percent of CD and UC cases, respectively, could have been prevented by adopting a healthy lifestyle. In the validation cohorts, from 43.9 to 51.2 and from 48.8 to 60.4 percent of CD cases and from 20.6 to 27.8 and from 46.8 to 56.3 percent of UC cases could have been prevented by adherence to low MRS and a healthy lifestyle, respectively.
“Further prospective intervention studies are needed to determine whether lifestyle modification is effective for the primary prevention of inflammatory bowel disease, particularly in the high-risk population and younger-onset disease,” the authors write.
Several authors revealed financial ties to the pharmaceutical industry.
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