Genetic and lifestyle factors are independently associated with incident thyroid cancer, according to a study published online December 12 in JAMA Open Network.
Xiuming Feng, of Guangxi Medical University in Nanning, China, and colleagues tested whether adherence to a healthy lifestyle modifies the association between genetic variants and thyroid cancer. The analysis included 264,956 participants (40 to 69 years of age) identified in the UK Biobank.
The researchers found that during a median follow-up of 11.1 years, 423 incident thyroid cancers were identified. There was a significant association between higher polygenic risk scores (PRS) and thyroid cancer (hazard ratio, 2.25), as well as a significant association between unfavorable lifestyle and increased risk of thyroid cancer (hazard ratio, 2.25). of instantaneous risks, 1.93). Unfavorable lifestyle was associated with thyroid cancer in the highest genetic risk group (favorable vs. unfavorable hazard ratio, 0.52). The highest risk of thyroid cancer was seen among participants with a high PRS and unfavorable lifestyle (hazard ratio, 4.89).
“The findings of this study suggest that adherence to a healthier lifestyle might attenuate the deleterious role of genetic factors in thyroid cancer risk, especially in people at high genetic risk,” the authors write. “Therefore, lifestyle interventions may be beneficial in preventing thyroid cancer, especially in people with a high genetic predisposition.”
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